The aim of the investigation was to develop and evaluate matrix type transdermal drug delivery systems (TDDS) of Dexamethasone. Dexamethasone is a steroid and used in a treatment of rheumatoid arthritis. The matrix type TDDS of Dexamethasone were prepared by solvent evaporation technique. Four formulations (composed of hydroxyl propylmethyl cellulose and poly vinyl pyrrolidone in the ratios of 9:1, 8:2, 7:3, 6:4 in formulations F1, F2, F3 and F4,) were prepared. 15 % w/v of propylene glycol as plasticizer in methanol and water as solvent system. The prepared transdermal patches were evaluated for in-vitro release, moisture absorption, tensile strength, drug content uniformity and mechanical properties. Preparation of standard curve for Dexamethasone in solution of 5 % methanolic phosphate buffer pH 6.8. In vitro drug release profile was performed by diffusion cell using above solution. Take absorbance at same time interval by UV spectrophotometer and calculate % drug release at particular time interval. The maximum drug release in 6 hrs for formulations was in the range of 85.75 % to 99.56 %. The mechanical properties, tensile strength, elastic modulus (0.204 kg/cm2 and 18.33 % for batch code F4) reveal that the formulations were found to be strong but not brittle. Average thickness (0.26 mm for F4), folding endurance 72 for F4 and % moisture uptake (4.78% for F4) also found in prepared patches. Drug content was 94.79 for F4 and swellability was 23.43 % for F4. Dexamethasone matrix type transdermal therapeutic systems could be prepared having suitable mechanical properties & sustained release dosage form. The permeation profile was matrix diffusion type.
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